:root{--lightningcss-light: ;--lightningcss-dark:initial;color-scheme:dark;--bg:#07090c;--card:#10141b;--panel:#161b24;--input:#0a0d12;--hover:#1b212c;--border:#1e2532;--border-strong:#2b3444;--text:#eef3fa;--muted:#93a1b5;--accent:#48d6ff;--accent-line:#1d8aad;--accent-dim:#48d6ff24;--accent-fill:#48d6ff42;--warn:#ffb454;--error:#ff6b7d;--ok:#57d9a3;--btn-text:#d3d8de;--btn-line:#5b6470;--btn-fill:#d3d8de1a;--btn-fill-hover:#d3d8de33;--scroll-thumb:#2b3444;--scroll-thumb-hover:#3b4759}*{box-sizing:border-box}[hidden]{display:none!important}*{scrollbar-width:thin;scrollbar-color:var(--scroll-thumb) transparent}::-webkit-scrollbar{width:11px;height:11px}::-webkit-scrollbar-track{background:0 0}::-webkit-scrollbar-thumb{background:var(--scroll-thumb);background-clip:content-box;border:3px solid #0000;border-radius:8px}::-webkit-scrollbar-thumb:hover{background:var(--scroll-thumb-hover);background-clip:content-box}::-webkit-scrollbar-corner{background:0 0}html,body{height:100%}body{background:var(--bg);color:var(--text);flex-direction:column;margin:0;font:14px/1.5 system-ui,-apple-system,Segoe UI,sans-serif;display:flex;overflow:hidden}.topbar{border-bottom:1px solid var(--border);background:var(--panel);padding:14px 22px}.brand{align-items:baseline;gap:10px;display:flex}.logo{font-size:22px}.brand h1{letter-spacing:2px;color:var(--accent);margin:0;font-size:22px}.subtitle{color:var(--muted);font-size:12px}.layout{--col-left:480px;--col-right:360px;--col-rail:30px;grid-template-columns:var(--col-left) minmax(0, 1fr) var(--col-right);box-sizing:border-box;flex:1;gap:18px;width:100%;min-height:0;padding:18px 22px 0;display:grid}.layout[data-left=collapsed]{--col-left:var(--col-rail)}.layout[data-right=collapsed]{--col-right:var(--col-rail)}.panel{min-width:0;min-height:0;display:flex;overflow:hidden}.pane-body{flex:1;min-height:0;padding-bottom:18px;overflow-y:auto}.panel.collapsed>.pane-body{display:none}@media (width<=1380px){.layout{--col-left:400px;--col-right:300px}}@media (width<=900px){body{display:block;overflow:auto}.layout{grid-template-columns:1fr}.panel,.panel.collapsed{display:block;overflow:visible}.panel.collapsed>.pane-body{display:block}.pane-body,#pane-right>.pane-body{display:block;overflow:visible}.assistant-card{height:auto}.chat-log{flex:none;max-height:45vh}}.pane-toggle{width:18px;color:var(--muted);cursor:pointer;font:inherit;letter-spacing:1px;text-transform:uppercase;background:0 0;border:none;flex:none;align-items:center;gap:6px;padding:0;font-size:11px;display:flex}.pane-toggle:hover{color:var(--accent)}.pane-toggle:focus-visible{outline:1px solid var(--accent);outline-offset:2px}.pane-toggle:before{content:"";background:var(--border);border-radius:2px;flex:none;align-self:stretch;width:3px;margin:2px 0 20px}.pane-toggle:hover:before{background:var(--accent-dim)}.pane-caret:after{content:"‹";font-size:15px;line-height:1}#pane-right .pane-caret:after,.panel.collapsed .pane-caret:after{content:"›"}#pane-right.collapsed .pane-caret:after{content:"‹"}.pane-name{display:none}.panel.collapsed>.pane-toggle{flex-direction:column;gap:10px;width:100%;padding-top:4px}.panel.collapsed .pane-name{writing-mode:vertical-rl;white-space:nowrap;display:block;transform:rotate(180deg)}.panel.collapsed>.pane-toggle:before{display:none}#pane-left>.pane-toggle{order:2}#pane-left.collapsed>.pane-toggle{order:0}@media (width<=900px){.pane-toggle,.panel.collapsed>.pane-toggle{display:none}}.card-head{justify-content:space-between;align-items:center;gap:10px;margin-bottom:10px;display:flex}.card-head h2{margin:0}#suggest-purpose,.head-select{min-height:24px;margin-left:auto;padding:2px 4px;font-size:11px}.head-select:disabled{opacity:.45;cursor:default}.card.section>summary{cursor:pointer;-webkit-user-select:none;user-select:none;padding-right:20px;list-style:none;position:relative}.card.section>summary::-webkit-details-marker{display:none}.card.section>summary:after{content:"▾";color:var(--muted);font-size:11px;transition:transform .15s;position:absolute;right:0}.card.section:not([open])>summary:after{transform:rotate(-90deg)}.card.section:not([open])>summary{margin-bottom:0}.card.section>summary:hover h2{color:var(--text)}.card.section:not([open]){padding-bottom:12px}.card{background:var(--card);border:1px solid var(--border);border-radius:10px;margin-bottom:14px;padding:14px 16px}.card h2{text-transform:uppercase;letter-spacing:1px;color:var(--muted);margin:0 0 10px;font-size:13px}select,textarea,button{font:inherit;color:var(--text);background:var(--input);border:1px solid var(--border);border-radius:7px}select{max-width:100%;padding:6px 8px}input[type=checkbox],input[type=radio]{accent-color:var(--accent)}textarea{resize:vertical;width:100%;margin-top:8px;padding:8px;font-family:ui-monospace,monospace;font-size:12px}.btn{cursor:pointer;background:var(--btn-fill);border-color:var(--btn-line);min-height:24px;color:var(--btn-text);padding:2px 9px;font-size:12px;font-weight:600}.btn:hover:not(:disabled){background:var(--btn-fill-hover);border-color:var(--btn-text)}.btn.small{margin-left:auto}.btn:disabled{opacity:.4;cursor:default;border-color:var(--border);color:var(--muted);background:0 0}#add-lane{text-align:left;text-overflow:ellipsis;white-space:nowrap;flex:1;overflow:hidden}.row{flex-wrap:wrap;align-items:flex-end;gap:10px;margin-top:10px;display:flex}.row label{color:var(--muted);flex-direction:column;gap:4px;font-size:12px;display:flex}label.inline{color:var(--text);flex-direction:row;align-items:center;gap:5px}.dna-search{box-sizing:border-box;width:100%;font:inherit;color:var(--text);background:var(--input);border:1px solid var(--border);border-radius:8px;margin-bottom:8px;padding:7px 9px;font-size:12.5px}.dna-search:focus{border-color:var(--accent);outline:none}#dna-search-note{margin-bottom:8px}.ncbi-results{flex-direction:column;gap:4px;max-height:260px;margin-top:8px;display:flex;overflow-y:auto}.ncbi-hit{text-align:left;font:inherit;cursor:pointer;color:var(--text);background:var(--input);border:1px solid var(--border);border-radius:8px;flex-direction:column;gap:2px;padding:6px 9px;font-size:12px;display:flex}.ncbi-hit:hover:not(:disabled){border-color:var(--accent)}.ncbi-hit .ncbi-title{text-overflow:ellipsis;white-space:nowrap;overflow:hidden}.ncbi-hit:disabled{cursor:not-allowed;opacity:.55}.ncbi-hit:disabled em{color:var(--warn);font-style:normal}.dna-groups details{border:1px solid var(--border);border-radius:8px;margin-bottom:6px;overflow:hidden}.dna-groups summary{cursor:pointer;text-transform:uppercase;letter-spacing:.5px;color:var(--muted);background:var(--panel);-webkit-user-select:none;user-select:none;padding:7px 10px;font-size:12px;font-weight:600}.dna-groups summary:hover{color:var(--text)}.dna-groups .count{float:right;color:var(--accent);font-weight:400}.dna-item{border:none;border-top:1px solid var(--border);cursor:pointer;text-align:left;background:0 0;border-radius:0;justify-content:space-between;align-items:baseline;gap:8px;width:100%;padding:6px 12px;display:flex}.dna-item:hover{background:var(--hover)}.dna-item.active{background:var(--accent-dim)}.dna-item.active .dna-name{color:var(--accent)}.dna-name{font-size:13px;font-weight:600}.dna-size{color:var(--muted);white-space:nowrap;font-size:11px}#config-name{background:var(--input);border:1px solid var(--border);color:var(--text);border-radius:7px;flex:1;padding:7px 10px;font-size:13px}.config-list{margin-top:10px}.config-row{align-items:stretch;gap:6px;margin-bottom:4px;display:flex}.config-row>.btn,.dna-line>.btn{align-self:center}.config-load{cursor:pointer;text-align:left;background:var(--panel);flex-direction:column;flex:1;align-items:flex-start;gap:1px;padding:6px 10px;display:flex}.config-load:hover{border-color:var(--accent)}.config-name{font-size:13px;font-weight:600}.btn.danger,.btn.danger:hover:not(:disabled){border-color:var(--error);color:var(--error);background:#ff6b7d24}#lib-status{min-height:1em;color:var(--accent);margin-top:8px}.dropzone{text-align:center;border:1px dashed var(--border);border-radius:8px;flex-direction:column;align-items:center;gap:5px;margin-top:10px;padding:14px 10px;transition:border-color .12s,background .12s;display:flex}.dropzone.over{border-color:var(--accent);background:var(--accent-dim)}.dropzone .hint{font-size:11px}#accession-input{background:var(--input);border:1px solid var(--border);min-width:0;color:var(--text);border-radius:7px;flex:1;padding:6px 9px;font-size:12px}#import-status{color:var(--muted);margin-top:6px}#import-status:empty{margin:0}#import-status.error{color:var(--error)}.dna-item.lazy .dna-size{color:var(--muted);opacity:.75;font-style:italic}body.busy{cursor:progress}body.busy .dna-item{pointer-events:none;opacity:.6}.dna-line{border-top:1px solid var(--border);align-items:stretch;display:flex}.dna-line .dna-item{border-top:none;flex:1}.dna-line .del-seq{opacity:0;margin:0 8px 0 4px}.dna-line:hover .del-seq,.dna-line .del-seq:focus-visible{opacity:1}.frag-feat{opacity:.75;font-family:system-ui,sans-serif;font-size:10px;line-height:1.3;display:block}.dna-meta{color:var(--muted);margin-top:8px;font-size:13px}.dna-meta strong{color:var(--text)}details summary{cursor:pointer;color:var(--muted);margin-top:8px;font-size:13px}.hint{color:var(--muted);font-size:12px}.filter-row{gap:6px}.filter-row input[type=search]{background:var(--input);border:1px solid var(--border);min-width:0;color:var(--text);border-radius:7px;flex:1;padding:6px 9px;font-size:12px}.filter-row select{padding:5px 6px;font-size:12px}.filter-row .inline{white-space:nowrap;font-size:12px}#enzyme-count{margin:6px 0 2px}.methyl-row{color:var(--muted);flex-direction:column;gap:4px;margin-top:10px;font-size:12px;display:flex}.methyl-row select{font-size:12px}.ends-info{background:var(--panel);border:1px solid var(--border);border-radius:7px;margin-top:8px;padding:7px 9px;font-size:12px}.end-row{margin:2px 0}.end-row code{color:var(--accent);background:var(--accent-dim);border-radius:4px;padding:0 4px;font-family:ui-monospace,monospace;font-size:12px}.end-row .hint{font-size:11px;display:block}.warning{color:var(--warn);background:#ffb45417;border:1px solid #ffb45457;border-radius:6px;margin-top:8px;padding:6px 9px;font-size:12px}.lane-notes{margin-top:3px}.blocked-note{color:var(--warn);font-size:11px}.enzyme.iis .esite{color:#7fb2c9}.enzyme-grid{grid-template-columns:1fr 1fr;gap:4px;margin:8px 0;display:grid}.enzyme{cursor:pointer;border:1px solid #0000;border-radius:6px;grid-template-columns:auto auto minmax(0,1fr) auto;align-items:center;gap:6px;min-width:0;padding:4px 8px;display:grid}.enzyme:hover{background:var(--hover);border-color:var(--border-strong)}.enzyme.nocut{opacity:.45}.ename{white-space:nowrap;font-size:13px;font-weight:600}.esite{color:var(--muted);text-overflow:ellipsis;white-space:nowrap;min-width:0;font-family:ui-monospace,monospace;font-size:11px;overflow:hidden}.ecuts{color:var(--accent);white-space:nowrap;font-size:11px}.exposure-row{color:var(--muted);flex-direction:column;gap:3px;margin-top:10px;font-size:12px;display:flex}.exposure-row input[type=range]{width:100%;accent-color:var(--accent);cursor:pointer}#exposure-value{color:var(--accent);font-family:ui-monospace,monospace}.gel-wrap{padding:10px}#gel-canvas{border-radius:6px;width:100%;height:560px;display:block}.lane-row{border-top:1px solid var(--border);padding:8px 0}.lane-row:first-child{border-top:none}.lane-head{align-items:center;gap:10px;display:flex}.lane-num{color:var(--muted);font-size:12px}.frags{margin-top:4px}.frag{background:var(--btn-fill);color:var(--btn-text);border-radius:5px;margin:2px 2px 0 0;padding:1px 7px;font-family:ui-monospace,monospace;font-size:12px;display:inline-block}#pane-right>.pane-body{display:flex;overflow:hidden}.assistant-card{flex-direction:column;flex:1;min-height:0;margin-bottom:0;display:flex}.assistant-card>.card-head,.assistant-card>.key-setup,.assistant-card>.key-saved,.assistant-card>.chat-form,.assistant-card>.chat-usage{flex:none}.key-setup .row{margin-top:0}#chat-key-input{min-width:0;font:inherit;color:var(--text);background:var(--input);border:1px solid var(--border);border-radius:8px;flex:1;padding:7px 9px;font-size:12.5px}#chat-key-input:focus{border-color:var(--accent);outline:none}.key-setup .hint{margin-top:7px;line-height:1.5}.key-setup a{color:var(--accent)}.key-saved{border-bottom:1px solid var(--border);align-items:center;gap:8px;margin-bottom:9px;padding-bottom:9px;display:flex}.key-saved code{color:var(--accent);background:var(--accent-dim);border-radius:4px;padding:1px 5px;font-family:ui-monospace,monospace}.key-saved .btn{margin-left:auto}.chat-log{flex-direction:column;flex:1;gap:7px;min-height:120px;padding:2px 2px 4px;display:flex;overflow-y:auto}.chat-msg{white-space:pre-wrap;overflow-wrap:anywhere;border-radius:9px;padding:7px 10px;font-size:12.5px;line-height:1.5}.chat-msg.assistant{white-space:normal}.chat-msg :first-child{margin-top:0}.chat-msg :last-child{margin-bottom:0}.chat-msg p{margin:0 0 8px}.chat-msg ul,.chat-msg ol{margin:0 0 8px;padding-left:20px}.chat-msg li{margin:2px 0}.chat-msg h1,.chat-msg h2,.chat-msg h3,.chat-msg h4{color:var(--text);text-transform:none;letter-spacing:0;margin:10px 0 6px;font-size:12.5px;font-weight:600}.chat-msg code{background:var(--input);border-radius:4px;padding:1px 4px;font-family:ui-monospace,monospace;font-size:11.5px}.chat-msg pre{background:var(--input);border:1px solid var(--border);border-radius:6px;margin:0 0 8px;padding:8px 10px;overflow-x:auto}.chat-msg pre code{background:0 0;padding:0}.chat-msg blockquote{border-left:2px solid var(--border);color:var(--muted);margin:0 0 8px;padding-left:9px}.chat-msg a{color:var(--accent)}.chat-msg table{border-collapse:collapse;margin:0 0 8px;font-size:11.5px}.chat-msg th,.chat-msg td{border:1px solid var(--border);text-align:left;padding:3px 7px}.chat-msg hr{border:none;border-top:1px solid var(--border);margin:10px 0}.chat-msg math{font-size:1.05em}.chat-msg .katex{display:inline-block}.chat-msg .katex math[display=block]{margin:6px 0;display:block}.chat-msg.assistant{background:var(--panel);border:1px solid var(--border)}.chat-msg.user{background:var(--accent-dim);border:1px solid var(--accent);color:var(--text);align-self:flex-end;max-width:92%}.chat-msg.error{border-color:var(--error);color:var(--error);background:#ff6b7d17}.chat-tool{color:var(--muted);padding-left:4px;font-size:11px;font-style:italic}.chat-tool:before{content:"⋯ "}.chat-suggestions{flex-direction:column;gap:4px;display:flex}.chat-suggestion{text-align:left;font:inherit;cursor:pointer;color:var(--muted);border:1px dashed var(--border);background:0 0;border-radius:8px;padding:5px 9px;font-size:11.5px}.chat-suggestion:hover{color:var(--accent);border-color:var(--accent);border-style:solid}.chat-form{align-items:stretch;gap:7px;margin-top:9px;display:flex}.chat-actions{flex-direction:column;gap:5px;display:flex}.chat-actions .btn{margin:0}#chat-input{resize:vertical;min-width:0;font:inherit;color:var(--text);background:var(--input);border:1px solid var(--border);border-radius:8px;flex:1;padding:7px 9px;font-size:12.5px}#chat-input:focus{border-color:var(--accent);outline:none}#chat-input:disabled{opacity:.5}.chat-usage{color:var(--muted);text-align:right;font-variant-numeric:tabular-nums;flex:none;margin-top:5px;font-family:ui-monospace,monospace;font-size:10.5px}.footnote{text-align:center;color:var(--muted);padding:10px 20px 24px;font-size:11px}